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341 The PARylation is also markedly increased in muscle and the liver of aged mice in parallel with robustly decline of NAD + levels

Parida S, Siddharth S, Sharma D

Defective pyruvate dehydrogenase complex deficiency with reduced acetyl-CoA production results in decreased production of reducing equivalents in the form of NADH and, thus, decreased ATP through the mitochondrial respiratory chain and, consequently, an energy deficit