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Patients on this protocol who also use metabolic support agents like Metformin should note that both agents activate AMPK, and physician oversight is warranted to avoid compounding effects on blood glucose that could theoretically cause hypoglycemia in susceptible individuals, though this has not been reported clinically with MOTS-c at standard doses

Hetta HF, Elsaghir A, Sijercic VC, et al (2024) Mesenchymal stem cell therapy in diabetic foot ulcer: an updated comprehensive review

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Therefore, promising therapeutic strategies should aim to selectively induce ferroptosis in tumor and immunosuppressive cells while protecting or reinvigorating CD8 + T cells