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Oxidative stress can impair aquaporin function, reducing the efficiency of cellular water uptake and retention

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Tucker, M., Liao, G., Park, J., Rosenfeld, M., Wezeman, J., Mangalindan, R., Ratner, D., Darvas, M., & Ladiges, W

In T2D patients (n = 25, age 2565), consumption of 1 g L-citrulline twice a day for 4 weeks reduces the T2D-induced increase in arginase activity and increases plasma nitrites, effects corroborated by improvement of ACh-induced relaxation in ex vivo mouse aortic rings incubated (24-h) in low or high glucose-containing media and increases in NO production in ECs treated with high glucose (Shatanawi et al., 2020)