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When combined with hyaluronic acid, the results were even more significant surpassing either treatment used alone.[5] While human joint trials are still lacking, this is a promising area of investigation, particularly for patients dealing with both excess weight and degenerative joint conditions

[27] Additionally, anyone with Lebers hereditary optic neuropathy (a rare inherited eye disease) must avoid cyanocobalamin injections, since B can precipitate rapid worsening of that condition

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For people following a plant-based diet that choose to exclude animal products, it can be difficult to get enough B12