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NRF2 orchestrates the upregulation of several antioxidant genes reliant on GSH, including GSR, solute carrier family 7 member 11 (SLC7A11), glutamatecysteine ligase catalytic subunit (GCLC), and glutamatecysteine ligase modifier subunit, as well as metabolic detoxification genes such as aldehyde dehydrogenase 1 family member A1 and aldoketo reductase family 1 member C1 in cancer cells [66]