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showed that changes in SDC-1 mechanical tension generate a tension gradient in SDC-1 under fluid shear force, with SDC-1 interacting differently with the cytoskeleton depending on substrate stiffness, affecting integrin-mediated signaling and focal adhesion formation [49]

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Treating each as non-negotiable is a central part of how to reconstitute peptides safely for serious research, and each one prevents a different kind of silent failure