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On the one hand, the chemical reactivity of penicillins is related to the electrophilic properties of the -lactam carbonyl, which is associated with the high tension within the -lactam ring fused to the thiazolidine ring ( The existence of interactions between thiols and -lactam antibiotics, both in vitro and in vivo , has long been known

This pathway increases NO production, essential for endothelial proliferation, vessel dilation, and new capillary formation, which may be particularly beneficial in ischemic or hypovascular musculoskeletal tissues [20, 24, 26, 39, 41]

The endogenous antioxidants evaluated in this study included GST, CAT, SOD, GPX, albumin, and total bilirubin