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In a study on breast cancer, ALA-treated MDA-MB-231 and 4T1 breast cancer cell lines both exhibited downregulated expression of EMT markers such as Snail, vimentin, and Zeb1, along with impaired cell migration capabilities [73]

Urgent research is required to identify synergistic combinations (e.g., FSP1 inhibitors with GPX4 inhibitors, ferroptosis inducers with IDO1/m6A inhibitors, and ferroptosis inducers with immune checkpoint blockade) that can simultaneously bypass multiple resistance pathways across diverse GBM subclones

L.StrainJ

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