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Nevertheless, advances in neuroimaging, biomarker analysis, and longitudinal cohort studies have enabled researchers to corroborate key mechanistic pathways in humans, particularly those involving neurotrophic deficits, hippocampal atrophy, and neurotransmitter dysregulation

Am J Pathol 179(3):136072 Braidy N et al (2009) Effects of kynurenine pathway metabolites on intracellular NAD synthesis and cell death in human primary astrocytes and neurons

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24 These mutations serve as key molecular discriminators between glioma subtypes and are highly prevalent in lower-grade diffuse gliomas (WHO grades IIIII) and secondary GBMs 25 but are largely absent in primary GBMs, which are predominantly IDH wild-type