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In some embodiments, R 5 is NH 2

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Weight Reduction Following Intensive Lifestyle Intervention in Adults with Obesity or Overweight (Study 3) Overview of Study 3 Study 3 (NCT04657016) was an 84-week trial with a 12-week intensive lifestyle intervention lead-in period (Week -12 to Week 0), followed by a 72-week randomized treatment period of ZEPBOUND versus placebo (Week 0 to Week 72) with a standard lifestyle intervention