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Moreover, mitochondrial DAMPs released from stressed cells-such as mtDNA and cardiolipin-serve as potent activators of pattern recognition receptors (e.g., TLR9, cGAS-STING, and NLRP3), perpetuating inflammation ( 6.3 Tissue- and metabolic context-dependent mitochondrial responses to infection Mitochondrial responses to infection are not uniform but vary according to tissue type, cell lineage, and the hosts metabolic state

Kaulmann A, Bohn T (2014) Carotenoids, inflammation, and oxidative stressimplications of cellular signaling pathways and relation to chronic disease prevention

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