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Once the autophagosome has formed around its target, a lysosome can merge with it, delivering its degradative enzymes to the enclosed, pathogenic cargo

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The protein structure analysis confirmed the occurrence of conserved pyridine nucleotide disulfide oxidoreductase (Pyr_redox) and pyridine nucleotide disulfide oxidoreductase dimerization (Pyr_redox_dim) domains in each GR

Disclosures: Guan-Zhen Wang: Nothing to Disclose, Teng Feng: Nothing to Disclose, Li-Ping Han: Nothing to Disclose, Zhi-Liang Lv: Nothing to Disclose, Ji-Chen Sha: Nothing to Disclose, Xiao-Ling Yuan: Nothing to Disclose, Long-Ling Li: Nothing to Disclose, Yong-Qiang Shan: Nothing to Disclose 2388 MULTICENTER STUDY ON INCIDENCE AND RISK FACTORS OF HEPATOCELLULAR CARCINOMA IN PATIENTS WITH AUTOIMMUNE HEPATITIS Jiwon Yang 1 Sun Young Yim 2 Kunhee Kim 3 Hye Won Lee 3 Jonggi Choi 4 , 1 Asan Medical Center, 2 Korea University Hospital, 3 Yonsei University College of Medicine, 4 University of Ulsan, Asan Medical Center Background: A recent European multicenter study found a low incidence of hepatocellular carcinoma (HCC) in autoimmune hepatitis (AIH), even after cirrhosis development