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Severe nausea requiring treatment discontinuation was rare in monotherapy trials, with only about 1% of participants in the REDEFINE 1 trial stopping treatment because of adverse events overall

Stop use and seek medical advice if you develop rash, shortness of breath, chest pain, severe swelling, persistent vomiting, or any unexpected or worsening symptoms

As noted above, there is very little known about how the tissue-specific architecture of ECM is established, and fibril-associated matricellular proteins must surely be the best candidates for such a role