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Funding The author(s) declare financial support was received for the research, authorship, and/or publication of the article

Conversely, silencing FUNDC1 reduced MAM formation, decreasing VEGFR2 and repressing angiogenesis (140)

Furthermore, this pathway may be beneficial for the rapid regulation of cellular iron homeostasis since the activation of Nrf2 and subsequently HO-1 increases Fe 2+ or because the activation of NCOA4, which induces ferritinophagy to further release Fe 2+ from FTH, seems to be a relatively slow process