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reported a decrease in sialic acid and superoxide dismutase (SOD) in unstimulated whole saliva in patients with DM1, and concluded that these lower values could explain the poorer oral hygiene of these patients.16 By contrast, other studies have described greater antioxidant activity in the saliva of patients with DM1 the antioxidant markers being seen to increase in parallel to HbA1c.13,17 In our study, the salivary GSSG/GSH ratio was increased in diabetic patients at the expense of two factors: an increase in GSSG and a decrease in GSH levels

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To interrogate the mechanisms underlying NRF2-directed regulation of this core gene set, we compared mean promoter (1 kb restricted) ChIP-seq signal in A549 for NRF2, p300, as well as the histone marks H3K4me3 and H3K27ac, which are enriched at promoters and enhancers, respectively

Samaniego F, Wise JF, Tao RH, Zhu H, Ao X, Chen Z, Zhuang W, Braun FK, Mathur R, Romaguera JE, Fayad L, Wang M , McLaughlin P, McDonnell TJ, Patel KP, Neelapu SS, Kwak LW, Berkova Z