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1 Introduction Diabetes mellitus (DM) is an escalating global health crisis, currently affecting over 537 million people worldwide, with projections indicating an increase to 643 million by 2030 and 783 million by 2045, according to the International Diabetes Federation ( Despite the widespread use of traditional diagnostic markers such as hemoglobin A1c (HbA1c), the oral glucose tolerance test (OGTT), and fasting plasma glucose (FPG), these methods have inherent limitations in capturing the dynamic and multifactorial nature of diabetes pathogenesis