benefits of bpc-157 for men and the Difference Between an Evidence Gap and a Cover-Up: What the entire human evidence base actually looks like, and the questions to ask next. — WellFounded BPC 157 Benefits: Heal &

: NNMT

HUBERMAN: My whole purpose in doing this episode is to highlight how these different molecules ought to work, how they've been shown to work in animal models, and therefore how they might be working in humans

Evaluation of: Glycerol production (a marker of lipolysis) 2-deoxyglucose uptake (a marker of insulin signaling) DNA synthesis (a marker of proliferation) What they found: AOD-9604 stimulated lipolysis dose-dependently from 10 M, with a plateau at 10 M Full hGH stimulated lipolysis to a similar maximum, but with different kinetics AOD-9604 did not affect glucose uptake or DNA synthesis at all, whereas hGH inhibited both (the classic lipotoxic GH effect) Fragments with different sequence (from the N-terminal part of hGH) had no lipolytic effect Why it matters: This was the first publication of AOD-9604

It should be mentioned that pharmacokinetic studies still report relatively short half-life of the substance in blood circulation