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This application is crucial for unraveling the roles of specific proteins in cellular activities, such as signal transduction, gene expression, and metabolic processes

B12 deficiency may occur due to poor diet, vegetarian/vegan lifestyle, malabsorption, aging, digestive disorders, or medications like metformin and PPIs

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Other strategies would involve using inhibitors that target Nrf2 such as, the quassinoid brusatol 79 , the alkaloid trigonelline 80 and the flavonoid luteolin 81 , all of which showed efficacy in inhibiting Nrf2 activity and prevented chemo-resistance