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simultaneously, the inflammatory cascade initiated by the passage of peripheral cytokines into the central nervous system compromises the structural integrity of astrocytes and their ability to reuptake glutamate, as well as leads to damage of oligodendrocytes, the glial cells that produce myelin (Kradttir and Attwell, 2007

Because it stimulates the bodys own growth hormone production, dosing needs to stay within physiologic limits to avoid excess IGF-1. If levels climb too high, she notes, you might get symptoms such as fluid retention, joint stiffness, carpal tunnellike numbness, or mild insulin resistance, though these effects are uncommon with conservative dosing and regular monitoring

A placebo-controlled crossover trial in 35 healthy middle-aged adults found taking a single 25-gram dose of freeze-dried wild blueberry powder improved performance on tests of cognitive function, particularly those involving more demanding mental tasks