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10.3389/fphar.2016.00201 Summary Keywords -sitosterol, ferroptosis, oxidative stress, cellular senescence, FEV, cross-species comparison Citation Fang Z, Xie L, Wang J, Li J, Pan Y, Chen L, Cao S, Zhou Q, Li S, Zhang C and Li L (2025) The pivotal regulatory role of the FEV-SLC7A11 axis in ferroptosis elucidates the anti-aging mechanism of -sitosterol in a cross-species study

In addition, patient DhLOs showed decreased expression of epithelial markers ( ECAD, EPCAM , and KRT18 ) and increased expression of mesenchymal markers ( ACTA2, COL1A1 , and VIM ), consistent with the presence of COL1A1-positive mesenchymal cells (Supplementary Fig