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In addition, as the global population ages, the societal and economic impact of age-related macular degeneration is poised to increase

Fourth, verifying the correlation between combined markersincluding the abundance of specific genera (e.g., decreased Bifidobacterium), iron metabolism indicators (e.g., elevated serum hepcidin), and pro-ferroptotic metabolites (e.g., increased TMAO)and OA clinical phenotypes through large-sample clinical studies, and exploring their diagnostic or prognostic value