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However, the amount of sample obtained from a given patient is always extremely limited, which is even more critical for diseases like ALS, a rare and rapidly progressing fatal orphan disease (ORPHA:803), limiting the number of patient samples obtained for analysis

188 Depletion of GSH impairs GPX4, halting the detoxification of lipid hydroperoxides and triggering unchecked lipid peroxidation 189

10.1177/2047487318756420 197 SchrammT

In terms of estimated impacts to the Medicare program, we believe that the proposals discussed in section III.B.2 of this final rule will have no impact on Medicare spending