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However, they also noted that the activation of Nrf2 could stimulate autophagy, a process that helps tumors survive in a nutrition-depleted environment [67]

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A randomized, placebo-controlled, double-blind trial on type 2 diabetic patients administered 600 mg/d EPA and 300 mg/d DHA supplementation for 10 wks disclosed that their Nrf2 expression levels were higher than those of placebo-treated controls [71]