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IFN- Drives Inflammatory Bowel Disease Pathogenesis through VE-Cadherin-Directed Vascular Barrier Disruption

While preclinical studies demonstrate promising results, clinical trials conducted thus far have yielded mixed outcomes, with some trials reporting limited or no therapeutic benefit

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43,62 In a study comparing zonisamide, topiramate, and placebo, treatment with zonisamide and topiramate each produced significant reductions in alcohol consumed per day, percent of days drinking, and percent of days with heavy drinking