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they made an impact on searching vitamin B 12 deficiency in MS and presumed aggravation of MS or impair recovery in B 12 deficiency.[15] Njist et al .[14] reported that B 12 concentrations in CSF (measured with a radioimmunoassay) and serum of MS patients were lower in control subjects

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Future trials should also measure important outcomes such as the clinical signs and symptoms of vitamin B 12 deficiency, health related-quality of life, socioeconomic effects, and report adverse events adequately, preferably in a primary care setting. Clinical practice guidelines British Columbia Medical Services Commission (MSC)