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Preclinical studies have shown that this peptide fragment can influence pathways associated with lipid metabolism and intracellular signalling without eliciting broad growth hormonemediated effects

However, in other epidemiological studies in prostate cancer patients these associations were not confirmed (75, 76)

The mice were housed in standard laboratory cages, with a maximum of 5 animals per cage, under SPF conditions, with regulation of temperature (22C 1C) and humidity (55%) and a 12-h:12-h dark-light cycle, and were free to get food and water

CLA isomeric blends at the same dose also showed no significant effects on plasma glucose or insulin levels in healthy human subjects [91]