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Abbreviations A: Amyloid beta AD: Alzheimers disease ADDF: Alzheimers Drug Discovery Foundation ADRD: Alzheimers disease and related dementias CDR: Clinical Dementia Rating CNS: Central nervous system CSF: Cerebrospinal fluid COX-2: Cyclooxygenase 2 D: Dasatinib D+Q: Senolytic therapy including the combination of Dasatinib and Quercetin FDA: Food and Drug Administration FOXO4: Forkhead box protein O4 FOXO4-DRI: FOXO4-D-Retro-Inverso PET: Positron emission tomography MAPK: Mitogen-activated protein kinas MDM2: Murine double minute 2 mTOR: Mammalian target of rapamycin MRI: Magnetic resonance imaging NFT: Neurofibrillary tangle OPC: Oligodendrocyte precursor cell PI3Kd: Phosphatidylinositol 3-kinase-delta PL: Piperlongumine Q: Quercetin ROS: Reactive oxygen species SToMP-AD: Senolytic Therapy to Modulate the Progression of Alzheimers Disease, acronym for clinical trial USP7: Ubiquitin-specific peptidase 7 TBI: Traumatic brain injury uPAR: Urokinase-type plasminogen activator receptor WAT: White adipose tissue References Mehegan, L., and Chuck Rainville

The two professionally accepted options each have specific characteristics, and understanding them is key to making the right choice for your research