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Bou Ghanem A, et al

Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene

This protective function may be key during early embryogenesis, when antioxidant capacity is limited and metabolic demands rapidly increase

The definition of two independent destruction domains implicated a more complex system of pVHL-HIF- interactions, but reinforced the role of prolyl hydroxylation as an oxygen-dependent destruction signal