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L-alanine is primarily used as a substrate for nascent protein production, whereas L-arginine availability shapes cellular fitness and viability 71,72

It has been found that gold nanoparticles can interact with fungal mitochondria, leading to inappropriate reduction of molecular oxygen during adenosine triphosphate (ATP) synthesis through coupled proton and electron transfer reactions and destruction of mitochondrial membrane [94]

For example, oncolytic adenoviruses and herpes simplex viruses have been engineered to selectively replicate within CSCs, leading to tumor cell lysis and the activation of antitumor immune responses

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