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Metabonomic and transcriptomics analysis showed that branched chain amino acid degradation, glycine synthesis, and glutamine metabolism pathways were significantly dysregulated in fatty liver, interacting with fatty acid metabolism and exacerbating liver lipid accumulation [45,46,47]

(Reference Haghighatdoost and Hariri17) Nevertheless, these claims are still controversial, both in matters of long-term effectiveness and dosages needed to evoke them

Mechanism of 5-lipoxygenase inhibition by acetyl-11-keto-beta-boswellic acid

In addition, melatonin protects against ferroptosis by reducing the expression of the H2O2-producing LOX enzymes [414, 418] and has the potential to do so by reducing the expression of the H2O2-producing NOX enzymes [419,420,421,422]

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