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Extracellular matrix and collagen research Beyond the wound-healing context, GHK-Cu is used in research on extracellular matrix biology more generally including collagen synthesis, the cross-linking reactions catalyzed by lysyl oxidase, the deposition and remodeling of matrix in various cell-culture systems, and the broader matrix metabolism that connects to tissue mechanics and tissue function

however, this does not necessarily mean exercise can be replaced by MOTS-c supplementation

Hair count increased significantly but hair thickness did not change

Without dermal penetration, you are coating the surface of the skin and failing to reach the fibroblasts