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Moreover, the activation of the post-junctional epithelial alpha-2 receptors prompts a decrease in the production of aqueous humor and an increase in uveoscleral outflow by curtailing intracellular cAMP levels [216,219,220]

The peptide spectra were recorded over a mass/charge (m/z) range of 350 to 1250, and MS/MS spectra were recorded over an m/z range of 150 to 1600 in data-dependent acquisition (DDA) mode

The activity of these enzymes also leads to the formation of 12-hydroxyheptadecatrienoic acid (12-HHTrE), which does not contain the prostanoic acid structure [108]

ROS are known to activate key cell proliferation pathways, including the Raf/MEK/ERK and mTOR signaling cascades, while also inducing chromatin alterations