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Acknowledgements Financial support was provided by the European Research Council ERC Grant Agreement 340896, LipoCheX (R.Z.), the DKs Molecular Enzymology (W901) (R.Z.) and Metabolic and Cardiovascular Disease (W1226) (F.M., D.K.), the SFB Lipotox (F30) funded by the Austrian Science Fund (FWF) (R.Z., F.M., D.K.), the Louis-Jeantet Foundation (R.Z.), the Fondation Leducq (grant 12CVD04) (R.Z.) and the BioTechMed-Graz flagship projects EPIAge (F.M.) and Lipid Signalling (D.K.)