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Our choice of metformin as a proof-of-concept test as a CI inhibitor 79 in these orthotopic models was based on several factors: (1) it could easily be taken forward safely into in vivo studies with known target concentrations

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Mashhadi NS, Zakerkish M, Mohammadiasl J, Zarei M, Mohammadshahi M, Haghighizadeh MH (2018) Astaxanthin improves glucose metabolism and reduces blood pressure in patients with type 2 diabetes mellitus