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While the general architecture of the cerebral cortex is conserved across these species, there are discrepancies in cell-type diversity and transcriptional regulation [168, 169], including divergence in gene expression in homologous cell types [170]

While older adults may experience slower regenerative responsesand therefore slower improvements compared with younger patientsthe overall safety profile remains high

Cancers with highly upregulated mTOR activity are frequently challenging to standard therapies, and reducing mTOR activity significantly impairs cancer growth by breaking their metabolic flexibility