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Pharmacokinetic Obstacles: The widespread clinical adoption of FOXO4-DRI is hindered by typical peptide-based limitations: rapid enzymatic degradation, low membrane permeability, and the requirement for injectable administration (PNAS, 2026)

We used 500 ng of total RNA isolated from WT and KO cells at PFG stage and day 8 of spontaneous differentiation, treated with H 2 O 2 , to prepare libraries (TruSeq RNA Library Prep Kit v2) according to the manufacturers protocol