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LC, ME/CFS and by extension POTS share gut microbiome features that underscore the criticality of bacterial GABA synthesis to proper functioning of the HPA axis, mediated by CVOs

Sixteen weeks after initiation of therapy Maralixibat was discontinued due to lack of efficacy

Likewise, exosomes derived from stromal cells reinforce tumor progression by transporting growth signals and metabolic substrates, underscoring the bidirectional nature of EV-mediated communication within the TME (125)

Future research should focus on evaluating the sustained efficacy and safety of urea and tretinoin over extended periods, providing insights into their long-term benefits and risks