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Using SH-SY5Y cells exposed to high glucose concentrations to induce hyperglycemia, disruptions in glucose sensing leads to activation of the phosphorylated protein kinase B (pAkt)/GSK-3 signaling pathway, and increased expression of BACE and A42, an effect that can be reversed via pretreatment with melatonin [62]

Therefore, it should be emphasized that high doses of vitamin E that are close to the upper limit of toxicity but still are recommended by manufacturers and considered harmless and beneficial, can potentially cause several adverse effects in the kidneys, also in humans

10.1002/adfm.202316092 162 WangD.LiuC.YouS.ZhangK.LiM.CaoY.et al (2020)

[5] studied peritoneal adhesions in rats