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Preclinical studies of FXR agonists have demonstrated improvements in hepatic steatosis, inflammation, fibrosis, and intestinal mucosal integrity, as well as reductions in plasma endotoxin and bile acids, in various liver-related disorders

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Drosophila melanogaster larvae exposed to 36C exhibited increased stress tolerance by elevating inducible heat-shock response expression of HSP70, albeit at a high energetic cost at the level of whole-organism metabolic rate