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If a second course is necessary, it cannot start until at least two months after the first

The failure of most targeted therapy trials for rGB can be attributed to their focus on the tumors initial mutational profile, which may not reflect the tumors current genetic state due to its evolution over time

The authenticity of this article has been validated by uploading the key raw data onto the Research Data Deposit public platform (www.researchdata.org.cn), with the approval RDD number as RDDB2025916508