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Extracellular vesicles can traverse the blood-brain barrier and facilitate communication among various cell types, undoubtedly, this property is a distinct EV characteristic that is unparalleled to conventional drug carriers (135, 136)

COMMON CHELATING AGENTS Among the various chelation therapy agents commercially available are 2,3-dimercaptopropan-1-ol (dimercaprol), sodium-calcium ethylenediaminetetraacetic acid (CaNa2EDTA), sodium 2,3-dimercaptopropane 1-sulfonate (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA)

After staining, sections undergo a series of alcohol dehydrations, clearing in xylene, and are then mounted with a neutral resin before being examined under a microscope (BDS400-FL, Ote, Chongqing) for histological evaluation