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Melasma can be stubborn, though and it may take a few months of treatment to see improvement

In point mutation assays with Salmonella typhimurium, the positive or equivocal responses obtained were all observed within a narrow dose range of up to 10-56 g per plate, higher doses being toxic

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Mice were placed into the water from one of the four starting points in a random order and the time taken to find the platform was recorded