Based on its complex mechanisms of actionspanning mitochondrial energy production, neurotransmitter synthesis, and neuroprotectionAcetyl-L-Carnitine has been studied for its ability to manage a specific cluster of debilitating symptoms
In addition to some animal studies with positive results, a double-blind, randomized controlled clinical trial found that healthy elderly people who took a supplement containing carnosine as well as anserine experienced an improvement in their age-related decline in brain blood flow (which occurs in Alzheimers disease) after three months of supplementation
BMJ 374:n1648 Cysique LA, Jakabek D, Bracken SG, Allen-Davidian Y, Heng B, Chow S, Dehhaghi M, Pires AS, Darley DR, Byrne A, Phetsouphanh C, Kelleher A, Dore GJ, Matthews GV, Guillemin GJ, Brew BJ (2022) Post-acute Covid-19 cognitive impairment and decline uniquely associate with kynurenine pathway activation: a longitudinal observational study
For example, in a study we referenced earlier, which entailed 52 weeks of tesamorelin administration in patients with HIV, the researchers found the peptide to be generally well tolerated. Importantly, tesamorelin caused no significant elevations in glucose, which would have represented a severe safety hazard given the relationship between hyperglycemia and diabetes.9 26 That being said, there are contraindications and potential side effects: Contraindications with tesamorelin Current research has yet to establish the safety of tesamorelin among women who are pregnant or breastfeeding
