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Indeed, an intrinsic problem with siRNA is that it acts as a Toll-like receptor 3 (TLR3) ligand, and lipid nanoparticle (LNP) formulations cause additional stimulation by cationic lipids of LNP 33,41,42

Although energy metabolism status can also regulate intracellular ROS levels (e.g., glucose deprivation leads to a marked increase in cellular ROS) [53,54,55,56], our study demonstrated that supplementation with energy substrates such as sodium pyruvate in GGCT-knockdown cell models did not induce significant alterations in intracellular ROS levels

IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity

This phase makes the toxins water-soluble, allowing easy excretion and removal from the body