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Viana CE, Bortolotto VC, Araujo SM, Dahleh MMM, Machado FR, de Souza PA, et al

Furthermore, it has been shown in other studies that the protective effects against cerebral ischemia-reperfusion injury, achieved by inhibiting ferroptosis, are partially diminished upon induction by RSL3 (125,132)

Hence, while treatments like chemotherapy, radiation, and immunotherapy initially showed promise, the emergence of resistant tumor cells decreased therapeutic effectiveness