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We have summarized the physiological and pathological mechanisms related to ferroptosis in MASLD (Figure 1) and summarized relevant research evidence

Crosstalk with other nonacylated PTMs Succinylated lysine possesses two negative charges that are larger than those of methylated lysine

Interestingly, the levels of glutathione and mitochondrial function, which were lower in older mice before taking GlyNAC, and oxidative stress, which was higher before GlyNAC, also were comparable to those found in younger mice after taking GlyNAC for six weeks

however, because information on aspartame exposure was collected before the occurrence of disease in the prospective cohort studies, the resulting non-differential (with respect to cancer outcome) misclassification would tend to bias results towards the null