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While the analysis of the entire PD cohort (including de novo patients and treated patients) in addition to the de novo patient-specific analysis allowed us to maximize statistical power to detect PD-associated changes, we also performed a dedicated analysis for treated patients only, using the same filtering and adjustment steps as for the entire PD dataset, to better distinguish changes in treated from treatment-nave patients

Additionally, GHK-Cu treatment notably upregulated HO-1 expression (Figure 6G) and downregulated NF-B p65 expression (Figure 6I)

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