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The slow-releasing H 2 S donor GYY4137 can kill seven different human cancer cell lines (HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11, and U2OS) in a concentration-dependent manner

Han F, Li S, Yang Y, Bai Z

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The reaction can be important in pathological processes because DNA and other macromolecules contain nucleophiles, and ,-conjugated carbonyls are major products of lipid peroxidation of polyunsaturated fatty acids