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In addition to accelerating the loss of metabolically competent hepatocytes and liver function, advanced fibrosis and cirrhosis restrict hepatic blood flow, increasing the risk of acute liver failure, HCC, and liver-related mortality (215)

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doi: 10.1038/s41392-025-02280-1, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Tugume L., Ssebambulidde K., Kasibante J., Ellis J., Wake R