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The underlying driver is chronic inflammationspecifically, dysregulated immune signaling involving TNF-, interleukins (IL-17, IL-23), and NF-B pathways

PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis

For instance, senescent hepatocytes located in the peritumoral region suppressed the immune response, thereby promoting the development of hepatocellular carcinoma (HCC) [41]

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